2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

PDF 88.0 MB

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-113261A
    (Rac)-Oleoylcarnitine 13962-05-5 98%
    (Rac)-Oleoylcarnitine is an endogenous acylcarnitine and a potential noncompetitive inhibitor of glycine transporter 2 (GLYT2) that can be used as a pain suppressant.
    (Rac)-Oleoylcarnitine
  • HY-113289R
    Brassicasterol (Standard) 474-67-9
    L-Ornithine (hydrochloride) (Standard) is the analytical standard of L-Ornithine (hydrochloride). This product is intended for research and analytical applications. L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective.
    Brassicasterol (Standard)
  • HY-113320R
    Etiocholanolone (Standard) 53-42-9
    Cimbuterol (Standard) is the analytical standard of Cimbuterol. This product is intended for research and analytical applications. Cimbuterol is a β-adrenergic receptor agonist.
    Etiocholanolone (Standard)
  • HY-113354R
    Anserine (Standard) 584-85-0
    Anserine (Standard) is the analytical standard of Anserine. This product is intended for research and analytical applications. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].
    Anserine (Standard)
  • HY-113410R
    3-Methylglutaric acid (Standard) 626-51-7
    3-Methylglutaric acid (Standard) is the analytical standard of 3-Methylglutaric acid (HY-113410). This product is intended for research and analytical applications. 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration.
    3-Methylglutaric acid (Standard)
  • HY-113410S
    3-Methylglutaric acid-d4 1219798-68-1 98%
    3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid (HY-113410). 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration.
    3-Methylglutaric acid-d4
  • HY-113468R
    3-O-Methyl-DL-DOPA (Standard) 7636-26-2
    3-O-Methyl-DL-DOPA (Standard) is the analytical standard of 3-O-Methyl-DL-DOPA. This product is intended for research and analytical applications. 3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency[4].
    3-O-Methyl-DL-DOPA (Standard)
  • HY-113626A
    Cyclopenin 19553-26-5 98%
    Cyclopenin ((±)-Isocyclopenine) is a racemate.
    Cyclopenin
  • HY-113739A
    (S)-Desmethylcitalopram 144025-14-9 98%
    (S)-Desmethylcitalopram is the isomer of Desmethylcitalopram hydrochloride (HY-113739). Desmethylcitalopram (DCIT) hydrochloride is the active metabolite of Citalopram (HY-121203). Desmethylcitalopram has antidepressant effects. Desmethylcitalopram also inhibits cytochrome P450-2D6，-2C19 with IC50s of 39.5 and 53.5 μM.
    (S)-Desmethylcitalopram
  • HY-114452A
    LY2940094 tartrate 1307245-87-9 98%
    LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models.
    LY2940094 tartrate
  • HY-114489B
    Haemanthamine hydrochloride 98%
    Haemanthamine hydrochloride is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine hydrochloride targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine hydrochloride has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities.
    Haemanthamine hydrochloride
  • HY-114682A
    Lenperone hydrochloride 24677-86-9 98%
    Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research.
    Lenperone hydrochloride
  • HY-114703S
    Eslicarbazepine-d3 98%
    Eslicarbazepine-d3 (BIA 2-194-d3) is the deuterium labeled Eslicarbazepine (HY-114703). Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.
    Eslicarbazepine-d3
  • HY-114899R
    Azamethiphos (Standard) 35575-96-3
    Azamethiphos (Standard) is the analytical standard of Azamethiphos (HY-114899). This product is intended for research and analytical applications. Azamethiphos is an organophosphate insecticide that inhibits AChE. Azamethiphos inhibits sea lice.
    Azamethiphos (Standard)
  • HY-114899S
    Azamethiphos-d6 1189894-02-7 98%
    Azamethiphos-d6 is deuterated labeled Azamethiphos (HY-114899). Azamethiphos is an organophosphate insecticide that inhibits AChE. Azamethiphos inhibits sea lice.
    Azamethiphos-d6
  • HY-115066A
    GSK1521498 free base (hydrochloride) 1007578-24-6 98%
    GSK1521498 free base (hydrochloride) is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base (hydrochloride) is being used for the treatment of disorders of compulsive consumption of food, alcohol, and agents.
    GSK1521498 free base (hydrochloride)
  • HY-115766S
    Anabaseine-d4 1020719-05-4 98%
    Anabaseine-d4 is the deuterium labeled Anabaseine (HY-115766). Anabaseine is a non-selective nicotinic agonist. Anabaseine stimulates all AChRs, preferentially stimulates skeletal muscle and brain α7 subtypes. Anabaseine is also a weak partial agonist at α4β2 nAChRs.
    Anabaseine-d4
  • HY-116016R
    Etilevodopa (Standard) 37178-37-3
    Chlorbenside (Standard) is the analytical standard of Chlorbenside. This product is intended for research and analytical applications. Chlorbenside is an organochlorine pesticide. Chlorbenside targets organism such as mites and ticks and possesses efficient ovicidal and larvicidal activities.
    Etilevodopa (Standard)
  • HY-116026R
    3-Hydroxycarbofuran (Standard) 16655-82-6
    3-Hydroxycarbofuran (Standard) is the analytical standard of 3-Hydroxycarbofuran. This product is intended for research and analytical applications. 3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor.
    3-Hydroxycarbofuran (Standard)
  • HY-116062A
    JNJ-7925476 129540-12-1 98%
    JNJ-7925476 is a triple reuptake inhibitor that selectively and potently inhibits the activity of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). JNJ-7925476 is rapidly absorbed into the blood and its concentration in the brain is 7-fold higher than that in plasma. The occupancy ED(50) values of JNJ-7925476 for SERT, NET, and DAT in the rat brain are 0.18, 0.09, and 2.4 mg/kg, respectively. JNJ-7925476 rapidly induces a significant increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex in a dose-dependent manner. JNJ-7925476 exhibits potent antidepressant-like activity in the mouse tail suspension test. These results suggest that JNJ-7925476 has in vivo efficacy in biochemical and behavioral models of depression.
    JNJ-7925476
Cat. No. Product Name / Synonyms Application Reactivity